Effect of nifedipine with and without sildenafil citrate on management of preterm labor in pregnant women

Effect of nifedipine with and without sildenafil citrate on management of preterm labor in pregnant women: a triple-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N382

Enrollment

126

Registered

2021-02-08

Start date

2021-02-19

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm labor. Preterm labor

Interventions

Intervention 1: Intervention group: Routine care plus nifedipine tablet (manufacture by Zahravi Pharmaceutical Co.) 20 mg every 8 hours for one day and sildenafil vaginal tablet (manufacture by Pars D

Eligibility

Sex/Gender

Female

Age

15 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age of 15 to 45 years, Pregnant women, Gestational age of 24 to 36 weeks

Exclusion criteria

Exclusion criteria: Proven chorioamnionitis, Cervical dilatation more than 4 cm, Rupture of the amniotic sac, Chronic diseases (hypertension, renal failure, diabetes) Tocolytic contraindication, Contraindication of nifedipine or sildenafil, Previous history of preterm labor

Design outcomes

Primary

Measure	Time frame
Gestational age. Timepoint: At delivery. Method of measurement: By taking history.;Neonatal birth weight. Timepoint: At delivery. Method of measurement: by scale.;Hospitalization of the neonate in NICU ward. Timepoint: After delivery. Method of measurement: Based on the medical record.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Seyedeh Arezoo Hoseini

Hamedan University of Medical Sciences

Arezoo.hoseini.md@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026