Effect of topical 5% tranexamic acid solution versus 20% azelaic acid cream in the treatment of post-inflammatory hyper-pigmentation patients with acne

Effect of topical 5% tranexamic acid solution versus 20% azelaic acid cream in the treatment of post-inflammatory hyperpigmentation patients with acne: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N356

Enrollment

Registered

2020-05-28

Start date

2020-06-04

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne. Acne

Interventions

Intervention 1: Intervention group 1: Topical 5% tranexamic acid solution. Intervention 2: Intervention group 2: Azelaic acid cream 20% twice daily for 12 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 45 years, Facial unilateral or bilateral acne,

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding, Using oral contraceptive pills, History of taking anti-hyperpigmentation in the past 3 months, History of deep vein thrombosis, History of myocardial infarction, History of stroke, Chronic renal disease, Color vision impairment

Design outcomes

Primary

Measure	Time frame
Improvement of hyperpigmentation due to acne. Timepoint: On 4, 8, and 12 weeks after the intervention. Method of measurement: By physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Elnaz Poostian

Hamedan University of Medical Sciences

elnaz_poostian@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026