Evaluating the effect of intravenous N-acetyl cysteine versus placebo in the treatment of patients with mild and moderate acute respiratory distress syndrome caused by COVID-19

Evaluating the effect of intravenous N-acetyl cysteine versus placebo in the treatment of patients with mild and moderate acute respiratory distress syndrome caused by COVID-19: A double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N355

Enrollment

Registered

2020-05-18

Start date

2020-06-04

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19, virus identified

Interventions

Intervention 1: Intervention group: Routine care plus intravenous infusion of N-acetyl cysteine 40 mg/kg/day diluted in 100 ml dextrose 5% for 3 days. Intervention 2: Control group: Routine care plus

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 70 years, Being hospitalized in intensive care unit in less than past 48 hours, Mild to moderate acute respiratory distress syndrome due to COVID-19, Bilateral pulmonary infiltration in chest X-ray or CT-scan, Respiratory distress with more than 24 breathe per minute

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding, Cardiopulmonary edema, Severe acute respiratory distress syndrome, Using antioxidant drugs, Chronic liver or renal disease, Contraindication of N-acetyl cysteine

Design outcomes

Primary

Measure	Time frame
Need to mechanical ventilation. Timepoint: Within 28 days after the intervention. Method of measurement: By physical examination.;The patient's clinical status. Timepoint: Within 28 days after the intervention. Method of measurement: Based on the World Health Organization's 7-score system.;Mortality rate. Timepoint: Within 28 days after the intervention. Method of measurement: Based on medical document.	—

Measure

Time frame

Need to mechanical ventilation. Timepoint: Within 28 days after the intervention. Method of measurement: By physical examination.;The patient's clinical status. Timepoint: Within 28 days after the intervention. Method of measurement: Based on the World Health Organization's 7-score system.;Mortality rate. Timepoint: Within 28 days after the intervention. Method of measurement: Based on medical document.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Abbas Taher

Hamedan University of Medical Sciences

t_anesthesia@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 22, 2026