Evaluating the effect of intravenous hydrocortisone, methylprednisolone, and dexamethasone in treatment of patients with moderate to severe acute respiratory distress syndrome caused by COVID-19

Evaluating the effect of intravenous hydrocortisone, methylprednisolone, and dexamethasone in treatment of patients with moderate to severe acute respiratory distress syndrome caused by COVID-19: A double blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N354

Enrollment

Registered

2020-05-12

Start date

2020-06-04

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19, virus identified

Interventions

Intervention 1: Intervention group 1: Routine care plus intravenous hydrocortisone 50 mg every 8 hours for 10 days. Intervention 2: Intervention group 2: Routine care plus intravenous methylprednisolo

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 70 years, Hospitalized in intensive care unit in less than past 48 hours, Mild to moderate acute respiratory distress syndrome due to COVID-19, Bilateral pulmonary infiltration in chest X-ray or CT-scan, Respiratory distress with more than 24 breathe per minute

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding, Cardiopulmonary edema, Severe acute respiratory distress syndrome, Using antioxidant drugs, Chronic liver or renal disease, Contraindication of N-acetyl cysteine

Design outcomes

Primary

Measure	Time frame
Need to mechanical ventilation. Timepoint: Within 28 days after the intervention. Method of measurement: By physical examination.;The patient's clinical status. Timepoint: Within 28 days after the intervention. Method of measurement: Based on the World Health Organization's 7-score system.;Mortality rate. Timepoint: Within 28 days after the intervention. Method of measurement: Based on medical document.	—

Measure

Time frame

Need to mechanical ventilation. Timepoint: Within 28 days after the intervention. Method of measurement: By physical examination.;The patient's clinical status. Timepoint: Within 28 days after the intervention. Method of measurement: Based on the World Health Organization's 7-score system.;Mortality rate. Timepoint: Within 28 days after the intervention. Method of measurement: Based on medical document.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Abbas Taher

Hamedan University of Medical Sciences

t_anesthesia@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026