The Effect of zinc supplementation versus placebo on the improvement of clinical symptoms among students with premenstrual syndrome

The Effect of zinc supplementation versus placebo on the improvement of clinical symptoms among students with premenstrual syndrome: a double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N347

Enrollment

Registered

2020-03-14

Start date

2020-04-08

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premenstrual syndrome. Premenstrual tension syndrome

Interventions

Intervention 1: Intervention group: Zinc sulfate capsule 220 mg (manufactured by Hakiman Daru Pharmaceutical Co.) daily for three months. Intervention 2: Control group: Placebo capsule (manufactured b

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 35 years, Premenstrual syndrome, Student resident of dormitory of Hamadan University of Medical Sciences,

Exclusion criteria

Exclusion criteria: Malnutrition, Sepsis, Acute meningitis, Unstable hemodynamic status, Diarrhea, Mood or psychological disorder

Design outcomes

Primary

Measure	Time frame
Severity of clinical symptoms of premenstrual symptoms. Timepoint: Before the intervention and then after first, second, third, and sixth months after the intervention. Method of measurement: Using Premenstrual Symptoms Screening Tool (PSST) questionnaire.	—

Secondary

Measure	Time frame
The severity of pain. Timepoint: Before the intervention and then after first, second, third, and sixth months after the intervention. Method of measurement: Using Visual analog Scale (VAS).;The severity of hemorrhage. Timepoint: Before the intervention and then after first, second, third, and sixth months after the intervention. Method of measurement: By taking history.;The duration of hemorrhage. Timepoint: Before the intervention and then after first, second, third, and sixth months after the intervention. Method of measurement: By taking history.	—

Measure

Time frame

The severity of pain. Timepoint: Before the intervention and then after first, second, third, and sixth months after the intervention. Method of measurement: Using Visual analog Scale (VAS).;The severity of hemorrhage. Timepoint: Before the intervention and then after first, second, third, and sixth months after the intervention. Method of measurement: By taking history.;The duration of hemorrhage. Timepoint: Before the intervention and then after first, second, third, and sixth months after the intervention. Method of measurement: By taking history.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mayam Ahmadi

Hamedan University of Medical Sciences

ahmadi_1011@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026