Effect of phototherapy with and without Clofibrate on the treatment of jaundice among icterus preterm neonates

Effect of phototherapy with and without Clofibrate on the treatment of jaundice among icterus preterm neonates: a double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N343

Enrollment

108

Registered

2020-03-07

Start date

2019-05-22

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm neonatal jaundice. Neonatal jaundice associated with preterm delivery

Interventions

Intervention 1: Intervention group: Phototherapy plus oral Clofibrate (manufactured by Zahravi Pharmaceutical Co.) 25 mg/kg daily for 48 hours. Intervention 2: Control group: Phototherapy for 48 hours

Eligibility

Sex/Gender

All

Age

1 Days to 28 Days

Inclusion criteria

Inclusion criteria: Age of 1 to 28 days, Pre-term infants 35 to 37 weeks, Neonatal jaundice,

Exclusion criteria

Exclusion criteria: Hemolytic hyperbilirubinemia, Symptoms of infection or neonatal sepsis, Electrolyte disturbance, Neonatal seizures, Indication of blood exchange, Feeding with dry milk

Design outcomes

Primary

Measure	Time frame
Mean reduction of total bilirubin. Timepoint: 24, 36 and 48 hours after the intervention. Method of measurement: By laboratory test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElham Hatami

Hamedan University of Medical Sciences

elham.hatamy@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026