Effect of oral contraceptive with gonadotropin-releasing hormone (GnRH) agonist versus Estradiol Valerate on the pregnancy continuity after frozen embryo transfer in infertile women

Effect of oral contraceptive with gonadotropin-releasing hormone (GnRH) agonist versus Estradiol Valerate on the pregnancy continuity after frozen embryo transfer in infertile women: a double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N342

Enrollment

128

Registered

2020-03-04

Start date

2019-07-23

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Artificial fertilization. Complications associated with artificial fertilization

Interventions

Intervention 1: Oral contraceptive pill once daily form the second day of the menstrual cycle for 12 days plus a subcutaneous injection of GnRH agonist 0.5 mg daily from the 15th day of the menstrual

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 40 years, Infertile women candidate for the embryo transfer process, Having more than 3 embryos for transfer, Having a healthy uterine cavity, Having constant embryo culture medium, Having a constant embryo transfer environment, Having constant fetal quality, Having fixed embryology,

Exclusion criteria

Exclusion criteria: Being a smoker, Idiopathic infertility, Patients with donated oocytes,

Design outcomes

Primary

Measure	Time frame
Pregnancy continuity after embryo transfer. Timepoint: 12 weeks after the intervention. Method of measurement: With ultrasonography.	—

Secondary

Measure	Time frame
Ectopic pregnancy. Timepoint: 12 weeks after the intervention. Method of measurement: With ultrasonography.;Polygamous pregnancy. Timepoint: 12 weeks after the intervention. Method of measurement: With ultrasonography.;Spontaneous abortion. Timepoint: 12 weeks after the intervention. Method of measurement: With ultrasonography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Fatemeh Jamshidi

Hamedan University of Medical Sciences

fatemejam13655@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026