Prophylactic effect of cefazolin-vancomycin versus ceftazidime-vancomycin on the infection of surgical site in patients undergoing open heart surgery

Prophylactic effect of cefazolin-vancomycin versus ceftazidime-vancomycin on the infection of surgical site in patients undergoing open heart surgery: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N324

Enrollment

434

Registered

2019-12-17

Start date

2020-01-05

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical wound infection. Infection of obstetric surgical wound

Interventions

Intervention 1: Intervention group: Cefazoline injection 2 to 3 g depending on patient's weight every 6 hours and vancomycin injection 15 mg/kg every 12 hours for 48 hours. Intervention 2: Interventio

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 65 years, Indication of open heart surgery. Hospitalization for more than three days

Exclusion criteria

Exclusion criteria: Hemodialysis patients, History of recurrent Freonocellus, Having an artificial valve or vascular graft

Design outcomes

Primary

Measure	Time frame
Superficial infection at the surgical site. Timepoint: On days 7, 14, 30 and 90 after surgery. Method of measurement: With clinical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Soroor Akbari

Hamedan University of Medical Sciences

suak1393@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026