Effect of local tranexamic acid versus placebo on the incidence of dry socket after mandibular impacted wisdom teeth surgery

Effect of local tranexamic acid versus placebo on the incidence of dry socket after mandibular impacted wisdom teeth surgery: a double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N313

Enrollment

Registered

2019-10-22

Start date

2019-01-21

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted wisdom teeth. Impacted teeth

Interventions

Intervention 1: Intervention group: Surgery of mandibular impacted wisdom teeth on one side plus placement of gel foam including tranexamic acid. Intervention 2: Control group: Surgery of mandibular i

Eligibility

Sex/Gender

All

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 30 years, Bilateral Mandibular impacted wisdom teeth,

Exclusion criteria

Exclusion criteria: Presence of infection or inflammation around the hidden teeth, Poor oral hygiene, Allergy to topical anesthesia, Analgesic and antibiotic use, Taking oral contraceptive pills, Smoking and drug use, Using antidepressants medications

Design outcomes

Primary

Measure	Time frame
The severity of pain. Timepoint: On the third, seventh and fourteenth days after surgery. Method of measurement: Using Visual Analogue Scale (VAS).;Elimination of blood clots. Timepoint: On the third, seventh and fourteenth days after surgery. Method of measurement: By clinical examination.;Mouth odor. Timepoint: On the third, seventh and fourteenth days after surgery. Method of measurement: By clinical examination.;The severity of swelling. Timepoint: On the third, seventh and fourteenth days after surgery. Method of measurement: By clinical examination.	—

Measure

Time frame

The severity of pain. Timepoint: On the third, seventh and fourteenth days after surgery. Method of measurement: Using Visual Analogue Scale (VAS).;Elimination of blood clots. Timepoint: On the third, seventh and fourteenth days after surgery. Method of measurement: By clinical examination.;Mouth odor. Timepoint: On the third, seventh and fourteenth days after surgery. Method of measurement: By clinical examination.;The severity of swelling. Timepoint: On the third, seventh and fourteenth days after surgery. Method of measurement: By clinical examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Tanaz Raeipoor

Hamedan University of Medical Sciences

t_ra30pour@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026