The effect of topical ointment containing Berberis vulgaris' extract versus placebo on the severity morning stiffness and range of motion in rheumatoid arthritis patients

The effect of topical ointment containing Berberis vulgaris' extract versus placebo on the severity of morning stiffness and range of motion in rheumatoid arthritis patients: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N310

Enrollment

Registered

2019-10-18

Start date

2019-10-23

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid arthritis. Rheumatoid arthritis with rheumatoid factor

Interventions

Intervention 1: Intervention group: Routine treatment plus using Eucerin-based ointment containing hydroalcoholic Berberis vulgaris' extract at 10% concentration, manufactured by the laboratory of the

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 60 years, Rheumatoid arthritis

Exclusion criteria

Exclusion criteria: Using narcotic substance or alcohol

Design outcomes

Primary

Measure	Time frame
The severity of morning stiffness of the joint. Timepoint: Before the intervention and 15 days after that. Method of measurement: By Visual Analog Scale (VAS).;The range of motion of the joint. Timepoint: Before the intervention and 15 days after that. Method of measurement: By physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Soleimani

Hamedan University of Medical Sciences

Coleimany.neda@gmail.com+98 81 3838 0283

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026