Effect of curcumin versus placebo on the improvement of sever traumatic brain injury

Effect of curcumin versus placebo on the improvement of sever traumatic brain injury: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N305

Enrollment

168

Registered

2019-10-04

Start date

2019-04-19

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head injury. Crushing injury of head

Interventions

Intervention 1: Intervention group: Routine treatment plus curcumin 10 mg/kg every 8 hours through nasogastric tube for 3 weeks. Intervention 2: Control group: Routine treatment plus serum normal sali

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 70 years, Head trauma with past 24 hours, Conscious level of 8 or less, Candidate for craniotomy surgery

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding, Low blood pressure, Absence of brain reflex, Renal failure

Design outcomes

Primary

Measure	Time frame
Consciousness level. Timepoint: Daily for three weeks. Method of measurement: Using the Glasgow Coma Score (GCS).;Improvement of neurological defect. Timepoint: 3 and 6 months after the intervention. Method of measurement: With clinical examination.;Nervous system function. Timepoint: 3 and 6 months after the intervention. Method of measurement: Based on the Glasgow Outcome Score (GOS).;Brain edema. Timepoint: 3 weeks after the intervention. Method of measurement: Using CT scan.	—

Measure

Time frame

Consciousness level. Timepoint: Daily for three weeks. Method of measurement: Using the Glasgow Coma Score (GCS).;Improvement of neurological defect. Timepoint: 3 and 6 months after the intervention. Method of measurement: With clinical examination.;Nervous system function. Timepoint: 3 and 6 months after the intervention. Method of measurement: Based on the Glasgow Outcome Score (GOS).;Brain edema. Timepoint: 3 weeks after the intervention. Method of measurement: Using CT scan.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Masoomeh Roostaei

Hamedan University of Medical Sciences

rostae@gmail.com+98 81 3364 0030

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026