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Comparison of the effect of Carob (Ceratonia Siliqua L) and Ginseng supplementation versus placebo on spermogram parameters and sexual function in infertile men

Comparison of the effect of Carob (Ceratonia Siliqua L) and Ginseng supplementation versus placebo on spermogram parameters and sexual function in infertile men: a double-blind randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120215009014N284
Enrollment
90
Registered
2019-06-13
Start date
2019-06-10
Completion date
Unknown
Last updated
2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male infertility. Male infertility

Interventions

Intervention 1: Intervention group 1: Capsule 500 mg including Carob (Ceratonia Siliqua L) three times a day for 12 weeks. Intervention 2: Intervention group 2: Capsule 500 mg including Ginseng three

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 40 years Primary infertile men Abnormality of at least one parameter of semen Body mass index less than 30

Exclusion criteria

Exclusion criteria: Chromosomal abnormalities, testicular insufficiency, varicocele, cryptorchidism Chronic diseases such as diabetes, kidney disease, infectious diseases, genital tract infection, or thyroid dysfunction Using drug or alcohol Using medications that disrupt spermatogenesis (methotrexate, nitrofurantoin, colchicine and chemotherapy) Use of pituitary suppressants (testosterone, GnRh analogues) or anti-androgens (cimetidine, spironolactone) Taking drugs result in ejaculation failure (alpha-blockers, antidepressants, phenothiazide) Taking drugs result in erection dysfunction (beta-blockers, thiazide diuretics, metoclopramides) Taking drugs such as anabolic steroids, cannabis, heroin or cocaine History of surgical procedures on the testes Contact with pesticides, heavy metals and solvents Use of antioxidant supplements in the last three months Intense physical activity Having a slimming diet

Design outcomes

Primary

MeasureTime frame
Assessing the spermogram parameters. Timepoint: 12 weeks after the intervention. Method of measurement: By laboratory test.;Assessing sexual function. Timepoint: 12 weeks after the intervention. Method of measurement: By history taking.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Seyedeh Zahra Masoumi

Hamedan University of Medical Sciences

zahramid2001@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026