Effect of vaginal nitroglycerin versus receiving nothing on cervical dilation in women with post-term pregnancy

Effect of vaginal nitroglycerin versus receiving nothing on cervical dilation in women with post-term pregnancy: a single-blind randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N282

Enrollment

Registered

2019-05-29

Start date

2019-06-22

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-term pregnancy. Post-term pregnancy

Interventions

Intervention 1: Intervention group: Prenatal routine cares plus vaginal nitroglycerin 40 mcg every 4 hours until three dose. Intervention 2: Just prenatal routine cares.

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 40 years Women with post-term pregnancy (gestational age above 40 weeks and 4 days) Nulliparous Singleton Cephalic presentation

Exclusion criteria

Exclusion criteria: Contraindication of nitroglycerine Previous cesarean section or any uterine scar Any chronic disease Vaginal bleeding or drainage Oligohydramnios Intrauterine growth restriction (IUGR)

Design outcomes

Primary

Measure	Time frame
Assessing the duration of time from induction to active phase of labor. Timepoint: 12 hours after the intervention. Method of measurement: With physical examination.;Assessing the amount of bleeding. Timepoint: 12 hours after the intervention. Method of measurement: With physical examination.;Measuring the neonatal pulse rate. Timepoint: 12 hours after the intervention. Method of measurement: With physical examination.;Measuring the maternal pulse rate. Timepoint: 12 hours after the intervention. Method of measurement: With physical examination.	—

Measure

Time frame

Assessing the duration of time from induction to active phase of labor. Timepoint: 12 hours after the intervention. Method of measurement: With physical examination.;Assessing the amount of bleeding. Timepoint: 12 hours after the intervention. Method of measurement: With physical examination.;Measuring the neonatal pulse rate. Timepoint: 12 hours after the intervention. Method of measurement: With physical examination.;Measuring the maternal pulse rate. Timepoint: 12 hours after the intervention. Method of measurement: With physical examination.

—

Secondary

Measure	Time frame
Assessing headache and nausea. Timepoint: 12 hours after the intervention. Method of measurement: By history taking.;Flushing and changes in blood pressure. Timepoint: 12 hours after the intervention. Method of measurement: Wth physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahboobeh Goodini

Hamedan University of Medical Sciences

mahboobeh.goodini@yahoo.com+98 81 3828 3939

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026