Effect of using Cloxacillin as an "Antibiotic Lock Solution" versus placebo on prevention of catheter-associated infection in hemodialysis patients

Effect of using Cloxacillin as an "Antibiotic Lock Solution" versus placebo on prevention of catheter-associated infection in hemodialysis patients: a single-blind randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N272

Enrollment

124

Registered

2019-04-30

Start date

2019-05-05

Completion date

Unknown

Last updated

2019-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Catheter-associated infection. Infection due to central venous catheter

Interventions

Intervention 1: Intervention group: Injection of 100 mg/dl Cloxacillin and 1000 IU/ml heparin intra-catheter in every dialysis for 4 weeks. Intervention 2: Control group: Injection of 100 mg normal sa

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 80 years Hemodialysis

Exclusion criteria

Exclusion criteria: Using immunosuppressive drugs

Design outcomes

Primary

Measure	Time frame
Assessing the catheter-associated infection. Timepoint: Every week for 4 weeks. Method of measurement: Through physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRanyar Abdi

Hamedan University of Medical Sciences

ranyarabdi@gmail.com+98 81 3838 0283

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026