Effect of isopropyl alcohol nasal inhalation and intravenous ondansetron versus placebo on nausea and vomiting in patients with head trauma

Effect of isopropyl alcohol nasal inhalation and intravenous ondansetron versus placebo on nausea and vomiting in patients with head trauma: a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N271

Enrollment

228

Registered

2019-04-28

Start date

2018-12-25

Completion date

Unknown

Last updated

2019-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and vomiting. Nausea and vomiting

Interventions

Intervention 1: Intervention group 1: Inhalation of saturated pad with 70% isopropyl alcohol for one minute at most 3 times in 2 minutes intervals. Intervention 2: Intervention group 2: Injection of i

Eligibility

Sex/Gender

All

Age

12 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age of 20 to 80 years Mild head trauma (GCS of 14 to 15) Nausea and vomiting

Exclusion criteria

Exclusion criteria: Severe trauma to other parts of the body Hypersensitivity to isopropyl alcohol nasal inhalation and ondansetron Inhalation disorder Mental disorder

Design outcomes

Primary

Measure	Time frame
Assessing the severity of nausea and vomiting. Timepoint: Before the intervention and at 2 and 4 and 6 and 10 minutes after the intervention. Method of measurement: Using visual analog scale (VAS).	—

Secondary

Measure	Time frame
Assessing the severity of headache. Timepoint: Before the intervention and at 2 and 4 and 6 and 10 minutes after the intervention. Method of measurement: Using visual analog scale (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammad Saleh Rasooli

Hamedan University of Medical Sciences

rasoulsl@yahoo.com+98 81 3364 0030

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026