Comparison of the effect of intravenous nitroglycerine versus placebo the hemodynamic responses in patients undergo elective non-cardiac surgery

Comparison of the effect of intravenous nitroglycerine versus placebo the hemodynamic responses in patients undergo elective non-cardiac surgery: a double blind randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N265

Enrollment

Registered

2019-03-05

Start date

2018-08-23

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: blood pressure. Condition 2: heart rate. Elevated blood-pressure reading, without diagnosis of hypertension Abnormality in fetal heart rate and rhythm complicating labor and delivery

Interventions

Intervention 1: Intervention group 1: Intravenous nitroglycerine 1 mic g/kg as single-dose before surgery. Intervention 2: Intervention group 2: Intravenous nitroglycerine 2 mic g/kg as single-dose be

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 65 years; Candidate for elective non-cardiac surgery; Weight less than 100 kg

Exclusion criteria

Exclusion criteria: Using anti-hypertensive or anti-depressive drugs; Hyperthyroidism or hypothyroidism; Diabetes, renal failure, heart failure, or liver disorder; A history of myocardial infarction; Hypotension; Bradycardia

Design outcomes

Primary

Measure	Time frame
Measuring systolic blood pressure. Timepoint: Before and 1, 3, 5 and 10 minutes after intubation. Method of measurement: Using sphygmomanometer.;Measuring diastolic blood pressure. Timepoint: Before and 1, 3, 5 and 10 minutes after intubation. Method of measurement: Using sphygmomanometer.;Measuring heart rates. Timepoint: Before and 1, 3, 5 and 10 minutes after intubation. Method of measurement: Using monitor machine.	—

Measure

Time frame

Measuring systolic blood pressure. Timepoint: Before and 1, 3, 5 and 10 minutes after intubation. Method of measurement: Using sphygmomanometer.;Measuring diastolic blood pressure. Timepoint: Before and 1, 3, 5 and 10 minutes after intubation. Method of measurement: Using sphygmomanometer.;Measuring heart rates. Timepoint: Before and 1, 3, 5 and 10 minutes after intubation. Method of measurement: Using monitor machine.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShabnaz Sharifi

Hamedan University of Medical Sciences

Shabnaz.sharifi@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026