The effect of vaginal Evening Primrose Oil capsule versus placebo on cervical ripening and delivery outcomes in nulliparous women

Study of the effect of vaginal Evening Primrose Oil capsule versus placebo on cervical ripening and delivery outcomes in nulliparous women: a double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N231

Enrollment

Registered

2018-08-24

Start date

2018-09-23

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delivery outcomes. Encounter for supervision of other normal pregnancy, third trimester

Interventions

Intervention 1: Intervention group: Vaginal Evening Primrose Oil capsule 500 mg twice with 2 hours interval during delivery. Intervention 2: Control group: Vaginal placebo capsule twice with 2 hours i

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age of 18 to 45 years; Nulliparous; Cephalic presentation of embryo and alive with normal patterns of embryonic heart rate; Embryonic weight of 2500 to 3500 g; Gestational age of 38 to 39 weeks; Bishop score of 4 or lower

Exclusion criteria

Exclusion criteria: Sensitivity of herbal medications; Amniotic fluid disorder; Preeclampsia; Diabetes; Placenta aberration; Placenta Previa; Indication of cesarean

Design outcomes

Primary

Measure	Time frame
Cervical ripening. Timepoint: During delivery. Method of measurement: With physical examination.;Neonate Apgar score. Timepoint: In the first and fifth minutes after delivery. Method of measurement: With physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Farideh Kazemi

Hamedan University of Medical Sciences

faridehkazemi21@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026