Effect of oral N-Acetylcysteine versus placebo on the severity of the clinical signs in patients with acne

Effect of oral N-Acetylcysteine versus placebo on the severity of the clinical signs in patients with acne: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120215009014N226

Enrollment

Registered

2018-07-01

Start date

2018-07-06

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne. Acne vulgaris

Interventions

Intervention 1: Intervention group: Capsule Doxycycline 100 mg twice a day for 8 weeks and ointment Clindamycin 1% or Benzyl peroxide 5% twice a day for 8 weeks and tablet N-Acetylcysteine 600 mg twic

Eligibility

Sex/Gender

All

Age

15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age of 15 to 65 years; Having acne

Exclusion criteria

Exclusion criteria: Pregnancy; Using asteroid in the past three months; Diabetes; Hypercholesterolemia; Renal or liver failure

Design outcomes

Primary

Measure	Time frame
Assessing the severity of clinical signs. Timepoint: Before and 4 and 8 weeks after intervention. Method of measurement: Through physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Zhra Ahmadi

Hamedan University of Medical Sciences

sunflower_4330@yahoo.com+98 81 3827 4184

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026