Effect of N - Acetylcysteine in the prevention of ototoxicity caused by vancomycin.

Effect of N - acetylcysteine in the prevention of ototoxicity caused by vancomycin in the treatment of peritonitis in patients undergoing peritoneal dialysis.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201202148032N2

Enrollment

Registered

2013-07-09

Start date

2012-09-28

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peritonitis. Peritonitis, unspecified

Interventions

Intervention 1: Intervention: Receiving vancomycin intraperitoneal 1g q 5 days plus N – acetylcysteine 600 mg BID orally for 21 days. Intervention 2: Control: Receiving vancomycin intraperitoneal 1g q

Treatment - Drugs

Intervention: Receiving vancomycin intraperitoneal 1g q 5 days plus N – acetylcysteine 600 mg BID orally for 21 days.

Control: Receiving vancomycin intraperitoneal 1g q 5 days for 21 days.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria : Patients with peritoneal dialysis because of kidney problems ; Patients who do not use ototoxic drugs ; Patients who have no previous hearing impairment Exclusion criteria : Baseline audiometry with hearing damage ; Patients who use other ototoxic drugs

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Autotoxicity. Timepoint: Baseline and 21 days after treatment with N-acetylcysteine. Method of measurement: Audiometry.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSima Abediazar

Tabriz University Of Medical Science

abediazars@tbzmed.ac.ir, dr.emamipour@gmail.com+98 41 1334 7054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026