Comparison of the effect of dexmedetomidine and melatonin on unconsciousness in patients after coronary artery bypass surgery.

Comparison of the effect of Dexmedetomidine and Melatonin on delirium in patients after coronary artery bypass graft surgery

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120214009011N3

Enrollment

Registered

2024-05-28

Start date

2024-05-01

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery bypass grafting. Atherosclerosis of other coronary vessels without angina pectoris

Interventions

Intervention 1: The first group receiving melatonin: The patients of this group receive 6 mg melatonin tablets one night before the operation, and normal saline is infused as a placebo during the oper

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with ASA grade II or III (American Society of Anesthesiology classification) Patients between 18 and 65 years old Candidate for coronary artery bypass surgery

Exclusion criteria

Exclusion criteria: Allergy to the drugs used in the study Positive history of psychological problems Positive history of taking sleeping pills

Design outcomes

Primary

Measure	Time frame
Delirium after surgery. Timepoint: at 0, 2, 4, 8, 12, 18, and 24 hours after surgery in the ICU. Method of measurement: Standard Test of Confusion Assessment Method for ICU (CAM-ICU).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGolzar Sharifian

Shiraz University of Medical Sciences

golzarsharifian@yahoo.com+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026