Epilepsy. Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
Conditions
Interventions
Intervention 1: antiepileptic drugs + placebo. Intervention 2: antiepileptic drugs, intervention with 240 mg of progestron (Mejestrol) tablets twice a day.
Placebo
Treatment - Drugs
antiepileptic drugs + placebo
antiepileptic drugs, intervention with 240 mg of progestron (Mejestrol) tablets twice a day
Sponsors
Research Department, Medical school, Isfahan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1- The women between 18 and 45 years of age who had clinically and electrographically documented refractory CPS or SGMS of temporal lobe origin; 2- All the women with demonstrated catamenial pattern of seizure exacerbation premenstrually between days 25 and 2 or during the entire luteal phase of the menstrual cycle between days 2 and 10; 3- The women with seizure exacerbation during the entire luteal phase with inadequate luteal phase cycles as documented by low serum progesterone levels less than 5 ng/ml during the mid-luteal phase; 5- The women who had premenstrual exacerbations with normal mid-luteal phase progesterone levels; 6- No pregnant and not lactating women who had no amenorrhea or had taken no major tranquilizers, antidepressant medications or OCP during 3 month prior to participate. Exclusion criteria: 1- Immigration; 2- Inaccessibility; 3- Giving up the participation; 4- Sever progesterone complications.
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Seizure frequencies per month. Timepoint: 1 month. Method of measurement: questionnaire. | — |
Primary
| Measure | Time frame |
|---|---|
| Seizure frequency. Timepoint: 3 months. Method of measurement: questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammadreza Najafi
Isfahan University of Medical Sciences
Outcome results
None listed