The efficacy of Nigella sativa on chronic rhinosinusitis

The efficacy of Nigella sativa nasal oil drop on chronic rhinosinusitis patients’ quality of life in comparison with placebo.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201202088961N1

Enrollment

Registered

2013-01-01

Start date

2012-10-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Rhinosinusitis. Sinusitis (chronic) NOS

Interventions

Intervention 1: Intervention:Nigella sativa oil in base of sesame oil. Intervention 2: Control:sesame oil.

Treatment - Drugs

Placebo

Intervention:Nigella sativa oil in base of sesame oil

Control:sesame oil

Eligibility

Sex/Gender

All

Age

16 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:existence of 2 major signs or one major and 2 minor signs of rhinosinusitis in patients; patients have at least 12 consecutive weeks' duration of rhinosinusitis;patients have proved rhinosinusitis by CT-scan; patients are 16 to 65 years old exclusion criteria: pregnant patient; patients who are taking daily corticosteroid drugs; immunocompromised patients; patients having fever more than 37.8c; existence of any polyp in the nasal cavity Drop out: patient drug intolerancy; patient pregnancy when using drug; fever more than 38.5 c when using drug; patient unwillingness to continue participating in clinical trial

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
SNOT-22 Questionnaire result score. Timepoint: before intervention day(0), and a weak after the end of intervention day(28). Method of measurement: SNOT-22 Questionnaire.;Facial pain/pressure. Timepoint: days (0), (28). Method of measurement: yes/ No.;Facial congestion/fullness. Timepoint: days (0), (28). Method of measurement: yes/ no.;Nasal obstruction/blockage. Timepoint: days (0), (28). Method of measurement: yes/ no.;Nasal discharge/purulence, discolored posterior drainage. Timepoint: days (0), (28). Method of measurement: yes/ no.;Hyposmia/anosmia. Timepoint: days (0), (28). Method of measurement: yes/ no.;Purulence on nasal examination. Timepoint: days (0), (28). Method of measurement: yes/ no.;Headache. Timepoint: days (0), (28). Method of measurement: yes/ no.;Fever (nonacute rhinosinusitis). Timepoint: days (0), (28). Method of measurement: yes/ no.;Halitosis. Timepoint: days (0), (28). Method of measurement: yes/ no.;Fatigue. Timepoint: days (0), (28). Method of measurement: yes/ no.;Dental pain. Timepoint: days (0), (28). Method of measurement: yes/ no.;Cough. Timepoint: days (0), (28). Method of measurement: yes/ no.;Ear pain/pressure/fullness. Timepoint: days (0), (28). Method of measurement: yes/ no.	—

Measure

Time frame

SNOT-22 Questionnaire result score. Timepoint: before intervention day(0), and a weak after the end of intervention day(28). Method of measurement: SNOT-22 Questionnaire.;Facial pain/pressure. Timepoint: days (0), (28). Method of measurement: yes/ No.;Facial congestion/fullness. Timepoint: days (0), (28). Method of measurement: yes/ no.;Nasal obstruction/blockage. Timepoint: days (0), (28). Method of measurement: yes/ no.;Nasal discharge/purulence, discolored posterior drainage. Timepoint: days (0), (28). Method of measurement: yes/ no.;Hyposmia/anosmia. Timepoint: days (0), (28). Method of measurement: yes/ no.;Purulence on nasal examination. Timepoint: days (0), (28). Method of measurement: yes/ no.;Headache. Timepoint: days (0), (28). Method of measurement: yes/ no.;Fever (nonacute rhinosinusitis). Timepoint: days (0), (28). Method of measurement: yes/ no.;Halitosis. Timepoint: days (0), (28). Method of measurement: yes/ no.;Fatigue. Timepoint: days (0), (28). Method of measurement: yes/ no.;Dental pain. Timepoint: days (0), (28). Method of measurement: yes/ no.;Cough. Timepoint: days (0), (28). Method of measurement: yes/ no.;Ear pain/pressure/fullness. Timepoint: days (0), (28). Method of measurement: yes/ no.

—

Secondary

Measure	Time frame
Side effects. Timepoint: before intervention and days 1,7,14,21,28. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad reza Masroorchehr

Shahid Beheshti University of Medical sciences,Faculty of Traditional Medicine

m.masroorchehr@sbmu.ac.ir, masroor_shahr@yahoo.com+98 218877352125

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026