Contrast-induced nephropathy. Nephropathy induced by heavy metals
Conditions
Interventions
Intervention 1: (1) The sodium bicarbonate solution will be prepared by adding 150 mL of 1000-mEq/L sodium bicarbonate to 850 mL of sodium chloride. Patients will receive the same dose of sodium bicar
Treatment - Drugs
(1) The sodium bicarbonate solution will be prepared by adding 150 mL of 1000-mEq/L sodium bicarbonate to 850 mL of sodium chloride. Patients will receive the same dose of sodium bicarbonate solution
(2) All patients will be received the same dose of sodium chloride (1 mL/kg/ h upper limit 100 mL/h) for 12 hours before and 12 hours after the procedure. The study drug (acetylcysteine 600 mg) will b
(3) All patients will be received the same dose of sodium chloride (1 mL/kg/h upper limit 100 mL/h) for 12 hours before and 12 hours after the procedure.
Sponsors
Qom University of Medical Sciences and Health Services
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients, who have at least one of the following risk factors: 1) Age>65 years, 2) Diabetes mellitus, 3) Heart failure (25%>ejection fraction>40%), 4) Renal insufficiency (creatinine³1.5mg/dl), 5) Control hypertension (systolic and diastolic blood pressure 160 mm Hg and >100 mm Hg, respectively)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease of contrast-Induced nephropathy. Timepoint: Serum creatinine and blood urea nitrogen (BUN) levels will be measured in the morning on the first day before coronary angiography (day 1) and in the morning on second day after the procedure. PH urine level will be measured in the morning on the day before and after coronary angiography. Method of measurement: Serum creatinine, blood urea nitrogen (BUN) and PH urine levels will be measured, and creatinine clearance will be calculated according to the Cockcroft-Gault equation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza Yeganeh khah
Qom University of Medical Sciences and Health Services
Outcome results
None listed