Myocardial Infarction. myocardial infarction specified as acute or with a stated duration of 4 weeks (28 days) or less from onset
Conditions
Interventions
Intervention 1: Control group: cold, Bloody cardioplegic solution (st. Thomas II based) is applied at an initial volume of 1000 mL in all patients. A second or third shot of 300 to 500 mL is given to
Treatment - Surgery
Control group: cold, Bloody cardioplegic solution (st. Thomas II based) is applied at an initial volume of 1000 mL in all patients. A second or third shot of 300 to 500 mL is given to patients with re
Intervention group: the initial dose delivered in the same route and the next cardiolpegia will be infused via retrograde catheter 200-300 ml after every distal anastomosis for CABG cases or 300-500 m
Sponsors
Rajaie cardiovascular medical and research center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: all patients undergoing cardiopulmonary bypass surgery at one operator service in our institution were prospectively screened for inclusion in the investigation. Consecutive patients with the following characteristics were selected for inclusion in the study: valvular with at least two vessels coronary disease. Exclusion criteria: total respiratory disability; renal failure (Cr > 2); age = 80 years old; history of MI in 4 weeks preoperatively; failure to retrograde catheter insertion; where total respiratory disability is any of: height-corrected FEV1 (1.1-1.4) and DLCO less than 30 percent predicted (Technical revisions to medical criteria for determinations of disability).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality. Timepoint: 30-day after surgery. Method of measurement: ID. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood level of IL18 in peripheral blood sample. Timepoint: before institution of CPB, on removal of aortic cross-clamp, 30 minutes, and 12 hours after completion of CPB. Method of measurement: Laboratory kit.;Blood level of Na in peripheral blood sample. Timepoint: before institution of CPB, on removal of aortic cross-clamp, 30 minutes after completion of CPB. Method of measurement: Laboratory kit.;Blood level of K in peripheral blood sample. Timepoint: before institution of CPB, on removal of aortic cross-clamp, 30 minutes after completion of CPB. Method of measurement: Laboratory kit.;Blood level of Ca in peripheral blood sample. Timepoint: before institution of CPB, on removal of aortic cross-clamp, 30 minutes after completion of CPB. Method of measurement: Laboratory kit.;Blood level of Lactate in peripheral blood sample. Timepoint: before institution of CPB, on removal of aortic cross-clamp, 30 minutes after completion of CPB. Method of measurement: Laboratory kit.;Blood level of Lactate/Pyruvate in peripheral blood sample. Timepoint: before institution of CPB, on removal of aortic cross-clamp, 30 minutes after completion of CPB. Method of measurement: Laboratory kit.;Blood level of HSCRP in peripheral blood sample. Timepoint: before institution of CPB, on removal of aortic cross-clamp, 30 minutes after completion of CPB. Method of measurement: Laboratory kit.;Blood level of HCO3 in peripheral blood sample. Timepoint: before institution of CPB, on removal of aortic cross-clamp, 30 minutes after completion of CPB. Method of measurement: Laboratory kit.;Blood level of PH in peripheral blood sample. Timepoint: before institution of CPB, on removal of aortic cross-clamp, 30 minutes after completion of CPB. Method of measurement: Laboratory kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Alireza Alizadeh Ghavidel
Rajaie heart center
Outcome results
None listed