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Postoperative nausea and vomiting after cesarean delivery

Treatment of postoperative nausea and vomiting after spinal anestheisa for cesarean delivery: a randomized comparison of midazoalm, ondansetron, and a combination

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201201308877N1
Enrollment
132
Registered
2012-02-05
Start date
2010-12-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative nausea and vomiting. Anaesthetic, unspecified

Interventions

Intervention 1: Group MO (n = 44) that received intravenous midazoalm 30 µg/kg combined with intravenous ondansetron 8 mg. Intervention 2: Group O (n = 44) which received intravenous ondansetron 8 mg
. Intervention 3: Group M (n = 44) received intravenous midazoalm 30 µg/kg.
Treatment - Drugs
Group MO (n = 44) that received intravenous midazoalm 30 µg/kg combined with intravenous ondansetron 8 mg
Group O (n = 44) which received intravenous ondansetron 8 mg
Group M (n = 44) received intravenous midazoalm 30 µg/kg.

Sponsors

Isfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with ASA I; age between 18 to 45 years old; scheduled for elective cesarean delivery under spinal anesthesia and signing written informed consent to participate in the present study. Exclusion criteria: patients who had smoking habit; obstetric complications or any evidence of fetal compromise; patients who had history of motion sickness; previous postoperative emesis; gastrointestinal disease or administration of antiemetic medication in the previous 24 hours; having allergy to the study drugs and any contraindication for spinal anesthesia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Postoperative nausea and vomiting. Timepoint: Half an hour afer Intevention. Method of measurement: Visual analogous scale(VAS).

Secondary

MeasureTime frame
Sedation. Timepoint: Half, 2,4 and 24 hours after intervention. Method of measurement: Ramsay sedation scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mitra Jabalameli

Isfahan University of Medical Sciences

mitrajabalameli@mui.ac.ir+98 31 1236 7001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026