Comparison of midazoalm, ondansetron, and a combination for treatment of postoperative nausea and vomiting after spinal anestheisa for cesarean delivery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201201302405N10

Enrollment

132

Registered

2012-02-16

Start date

2010-10-12

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complications of anaesthesia during pregnancy. Other complications of anaesthesia during pregnancy

Interventions

Intervention 1: intravenous midazoalm 30 µg/kg. Duration of intervention: single dose in 10 seconds if patients have vomiting or VAS of nausea = 3. Duration of treatment: on demand after umbilical c

Treatment - Drugs

intravenous midazoalm 30 µg/kg. Duration of intervention: single dose in 10 seconds if patients have vomiting or VAS of nausea = 3. Duration of treatment: on demand after umbilical cord clamping, Du

intravenous ondansetron 8 mg. Duration of intervention: single dose in 10 seconds if patients have vomiting or VAS of nausea = 3. Duration of treatment: on demand after umbilical cord clamping, During

intravenous midazoalm 30 µg/kg combined with intravenous ondansetron 8 mg. Duration of intervention: single dose in 10 seconds if patients have vomiting or VAS of nausea = 3. Duration of treatment: on

Eligibility

Sex/Gender

Female

Age

16 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Parturients; ASA physical status I-II; scheduled for elective cesarean section; using spinal anesthesia; Exclusion Criteria: suspicious to bleeding disturbances; atopia; diabetes mellitus; presence of liver or kidney diseases; drugs abuse; complicated pregnancy; preeclampsia

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Frequency of nausea and vomiting. Timepoint: at recovery, 4, 8, 12 and 24 hours after surgery. Method of measurement: counting.;Nausea intensity. Timepoint: at recovery, 4, 8, 12 and 24 hours after surgery. Method of measurement: Visual Analogous Scale (VAS) and scoring from 0 to 10.	—

Secondary

Measure	Time frame
Opioid consumption. Timepoint: at recovery, 4, 8, 12 and 24 hours after surgery. Method of measurement: in milligramme of opioid.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mitra Jabalameli

Isfahan University of Medical Sciences

jabalameli@med.mui.ac.ir+98 31162555551532

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026