The efficacy of Simvastatin in maxillary sinus augmentation

Radiographic analysis of the efficacy of Simvastatin in combination with bone graft with bovis origin in maxillary sinus augmentation: A randomized controlled clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120127008830N5

Enrollment

Registered

2018-02-23

Start date

2018-02-09

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bone loss in the posterior maxillary edentulous ridge.

Interventions

Intervention 1: Control side: Each subject takes 2 gr amoxicillin or 600 mg clindamycin as antibiotic prophylaxis one hour before surgery. Clinical photographs are taken before, during and post-surge

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with age over 18 Desiring to receive maxillary posterior implants Not having sufficient bone determined on CBCT for dental implant The patients are partially or completely toothless in the posterior maxilla Patients who need bilateral maxillary sinus augmentation surgeries

Exclusion criteria

Exclusion criteria: Needing antibiotic prophylaxis for dental procedures Any sinus pathology (acute or chronic) contraindicating the sinus graft surgery Patients with systemic disease contraindicating any oral surgeries Patients who smoke more than 10 cigarettes daily Women who are pregnant or wish to become pregnant during the period of the study Diseases or medications known to affect bone metabolism ,tissue regeneration and repair such as corticosteroids, bisphosphonates and etc Patients with a history of alcoholism or drug abuse Patients who have a history of cancer or radiation to the head and neck

Design outcomes

Primary

Measure	Time frame
Alveolar bone height on Cone Beam Computed Tomograghy. Timepoint: Preoperative, immediately and 9 months after sinus graft. Method of measurement: Cone Beam Computed Tomography:Two lines which are the mesial and distal limits of the augmented area and a center point between these two lines were selected on Cone Beam Computed Tomographys that were taken. Alveolar bone height in these three lines measured and the average of these measurements was reported as mean alveolar bone height.;Alveolar bone density on Cone Beam Computed Tomograghy. Timepoint: preoperatively, immediately and at 9 months after sinus graft. Method of measurement: Cone Beam Computed Tomography.	—

Measure

Time frame

Alveolar bone height on Cone Beam Computed Tomograghy. Timepoint: Preoperative, immediately and 9 months after sinus graft. Method of measurement: Cone Beam Computed Tomography:Two lines which are the mesial and distal limits of the augmented area and a center point between these two lines were selected on Cone Beam Computed Tomographys that were taken. Alveolar bone height in these three lines measured and the average of these measurements was reported as mean alveolar bone height.;Alveolar bone density on Cone Beam Computed Tomograghy. Timepoint: preoperatively, immediately and at 9 months after sinus graft. Method of measurement: Cone Beam Computed Tomography.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShakiba Farahani

Dentistry School, Tehran University of medical Science

farahanishakiba@yahoo.com+98 21 8801 5950

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026