Major Depressive Disorder. Depressive episode
Conditions
Interventions
Intervention 1: Patients in this group receive thiopental (bolus 2-3 mg/kg) as anesthetic agent for 6 electroconvulsive treatment. Intervention 2: Patients in this group receive ketamine (bolus 1-2
Treatment - Drugs
Patients in this group receive thiopental (bolus 2-3 mg/kg) as anesthetic agent for 6 electroconvulsive treatment
Patients in this group receive ketamine (bolus 1-2 mg/kg) as anesthetic agent for 6 electroconvulsive treatment
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria : MDD( diagnosed on the basis of DSM IV criteria) ;HAM-D score greater than 18 Exclusion Criteria: History of any serious underlying conditions ( active CV or renal insufficiency); neurological disorders ( bulky mass or history of seizure disorders); other psychiatric diagnosis such as schizophrenia, schizoform or schizoaffective disorders, bipolar affective disorder; history of drug abuse in past six months; receiving electroconvulsive therapy in the past 6 months, verbal or auditory disorders (for ability to perform diagnostic tests)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in depression severity. Timepoint: before the first and second and after the 6th sessions of electroconvulsive therapy and 1 month after that. Method of measurement: Hamilton Rating Scale for Depression. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function. Timepoint: before the first and second electroconvulsive therapy ,after the 6th and 1 month after that. Method of measurement: Mini–mental state examination.;Seizure duration. Timepoint: in every ECT session. Method of measurement: chronometer.;Hemodynamic changes (blood presure, heart rate). Timepoint: brfore and after each electroconvulsive therapy session. Method of measurement: pulseoxymeter, sphyngomanometer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Padideh Ghaeli
Faculty of Pharmacy, Tehran University of Medical Scienses
Outcome results
None listed