mood disorde. bipolar affective disorder/ depressive disorder
Conditions
Interventions
Intervention 1: celecoxib 200 mg BID from a day before first ECT. Intervention 2: placebo with the same order and number as celecoxib.
Treatment - Drugs
Placebo
celecoxib 200 mg BID from a day before first ECT
placebo with the same order and number as celecoxib
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: diagnosis of mood disorder according to DSM IV TR criteria by a psychiatrist. Exclusion Cirteria: Patients with Hypersensetivity to celecoxib or other NSAIDs, Patients with rheumatologic disease, Organic Brain Syndrome, Severe Medical Conditions (cardiovascular disorders, hepatic, renal, respiratory, gasterointestinal), diabetes, patients undegoing treatment with of other NSAIDs or corticosteroides, receiving ECT in the past 2 months, hearing or talking problem and pregnanant patients were excluded.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in inflammatory factors. Timepoint: baseline, after ECT 1,3,6. Method of measurement: serum sample.;Change in cognition and memory. Timepoint: baseline, after ECT 1,3,6,. Method of measurement: MMSE,WMS and Stroop. | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy. Timepoint: baseline. after ECT 1,3,6. Method of measurement: Hamilton, YMRS. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Padideh Ghaeli
Faculty of Pharmacy of Tehran University of Medical Scienses
Outcome results
None listed