Helicobacter pylori infection. Helicobacter pylori
Conditions
Interventions
Intervention 1: Intervention Group:Pantoprazul (BD40mg) and amoxicillin (If keratinize clearance is between 10-30:250-500mg BD and if it is less than 10:250-500 mg Daily)for 5 days and Then Pantopraz
Treatment - Drugs
Intervention Group:Pantoprazul (BD40mg) and amoxicillin (If keratinize clearance is between 10-30:250-500mg BD and if it is less than 10:250-500 mg Daily)for 5 days and Then Pantoprazul (40mg BD) and
Control Group : Pantoprazul (40mg BD) and Claritromicine(250 mg BD)and Amoxicillin (If Kratinize Cearance is between 10-30:250-500mg BD and if it is less than 10:250-500 mg Daily)
Sponsors
Department of Research and Technology, Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with dyspepsia symptoms over the past one month from gastroenterology or nephrology clinic or hospital dialysis ward who have infection with H. Pylori confirmed by rapid urease test and biopsy in endoscopy. Exclusion Criteria : taking antibiotic regimen to eradicate H. pyloriand or receiving proton pump inhibitors, Bismuth, or NSAID during the last month; concomitant anticoagulant, corticosteroid or Ketoconazole; history of gastric or esophageal surgery; sensitivity to antibiotics; negative endoscopic biopsy; drinking alcohol and smoking; pregnancy and lactation; severe heart disease; diseases of the thyroid gland or liver cancer; chronic renal failure patients who are prior to stage 5 or have not received renal replacement therapy.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication of Helicobacter pylori Infection. Timepoint: At the end of four weeks after treatment. Method of measurement: Urea Test.;Eradication of Helicobacter pylori Infection. Timepoint: At the end of four weeks after treatment. Method of measurement: Creatinine Clearance Test.;Eradication of Helicobacter pylori Infection. Timepoint: At the end of four weeks after treatment. Method of measurement: Stool examination.;Eradication of Helicobacter pylori Infection. Timepoint: At the end of four weeks after treatment. Method of measurement: Biopsy by Endoscopic. | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute Renal Failure. Timepoint: At the first and second weeks of treatment. Method of measurement: Testing Urea.;Acute Renal Failure. Timepoint: At the first and second weeks of Treatment. Method of measurement: creatinine clearance test.;Acute Renal Failure. Timepoint: at the first and second weeks of treatment. Method of measurement: weight. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Atieh Makhlough
Mazandaran University of Medical Sciences
Outcome results
None listed