The effect of plasma rich in growth factors in treatment of gingival recession

Clinical evaluation of the efficacy of plasma rich in growth factors with connective tissue graft in treatment of gingival recession

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201201168747N1

Enrollment

Registered

2012-08-26

Start date

2012-05-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival Recession. Gingival recession (generalized)(localized)(post infective)(post-operative)

Interventions

Intervention 1: Control group: connective tissue graft with coronally flap advancement. Intervention 2: Intervention group: Moistened connective tissue graft with plasma rich in growth factors and cor

Treatment - Drugs

Control group: connective tissue graft with coronally flap advancement

Intervention group: Moistened connective tissue graft with plasma rich in growth factors and coronally advanced flap

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria : 1) The presence of either bilateral isolated or multiple facial defects with recession depths =2 mm when measured from the cementoenamel junction at anterior teeth or premolars; 2) The defects that are judged as Miller Class I or Class II; 3) The selected teeth should be vital, free of restorations or had restorations removed, and with no bleeding upon probing; 4)The age of patients should be within 18 to 65 5) Good oral hygiene (O´Leary plaque score =%20 ); 6)Width of keratinized gingiva should be 0.5mm. Exclusion criteria: 1) Smoking; 2) Any uncontrolled local or systemic disease that might contraindicate periodontal surgery; 3) Pregnancy; 4) Hematologic disorders; 5) Usage of the drugs that have intervention with wound healing (corticosteroid, chemotherapeutic agents); 6) Usage of the drugs that have intervention with platelet aggregation; 7) Allergy to tetracycline; 8) Traumatic methods of tooth brushing; 9) Applying abrasive dentifrices; 10) Applying removable partial denture; 11) The history of periodontal surgery at the selected site.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Gingival recession. Timepoint: Six month after surgery. Method of measurement: Clinical examination.	—

Secondary

Measure	Time frame
Width of keratinized gingiva. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Clinical attachment level. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Clinical probing depth. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Vertical depth of gingival recession. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Width of gingival recession. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Gingival thickness. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Gingival index. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;The distance between mucogingival junction and cementoenamel junction (Mgjl). Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.	—

Measure

Time frame

Width of keratinized gingiva. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Clinical attachment level. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Clinical probing depth. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Vertical depth of gingival recession. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Width of gingival recession. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Gingival thickness. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;Gingival index. Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.;The distance between mucogingival junction and cementoenamel junction (Mgjl). Timepoint: Baseline, 1 and 6 month after surgery. Method of measurement: Clinical examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Zahedi

Babol Dental School

dr.ehsanzahedi@mubabol.ac.ir+98 11 1229 1093

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026