Upper Gastrointestinal Bleeding. Acute haemorrhagic gastritis
Conditions
Interventions
Intervention 1: Interventio group: In addition to conventional therapy, we add 1 gram tranexamic acid, diluted into 500cc normal saline, to gastric washing fluid. we used Tranexamic Acid Ampule manifa
Treatment - Drugs
Interventio group: In addition to conventional therapy, we add 1 gram tranexamic acid, diluted into 500cc normal saline, to gastric washing fluid. we used Tranexamic Acid Ampule manifactured by Caspia
Control group: In addition to conventional therapy, we add free water (similar to tranexamic acid ampule) to fliud water for gastric washing.
Sponsors
Private Resiurces (Attending and Resident of incharge)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Symptoms or signs of GI bleeding. Exclusion Criteria: Pregnancy; Lactation; Gastrointestinal Malignancy; Coagulopathy; History of Thromboembolism; History of myocardial infarction or ischemic cerebrovascular accident; End Stage Renal Disease; Allergy to TA; Undergoing anticoagulation therapy; Congenital or acquired coagulopathy; who were reluctant to enroll in this study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Packed RBC. Timepoint: from intervention to discharge. Method of measurement: patient hospital document. | — |
Secondary
| Measure | Time frame |
|---|---|
| 30-day Mortality. Timepoint: From intervantion to 1 month later. Method of measurement: Patients' Hospital Document and Phone Contact.;Tranexamic Acid Complication. Timepoint: during the study. Method of measurement: According to clinical manifestation, physical examination and doppler sonography.;Re-bleeding. Timepoint: From intervention to Discharge. Method of measurement: Patients' Hospital Document. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahdi Rezai
Tehran University of Medical Sciences
Outcome results
None listed