Trauma. Intracranial injury,Crushing injury of head,Traumatic amputation of part of head,Other and unspecified injuries of head
Conditions
Interventions
Intervention 1: Patients in the control group receive the Full-caloric diet. Once hemodynamically stable, they receive a target of 90-100% of caloric requirement (estimated by simple equation of rule
Treatment - Other
Patients in the control group receive the Full-caloric diet. Once hemodynamically stable, they receive a target of 90-100% of caloric requirement (estimated by simple equation of rule of thumb that is
Patients in the intervention group receive the Hypo-caloric diet. After heamodynamically stabled, these patients are fed enterally with the permissive underfeeding method and they receive 40-50% of re
Sponsors
Mashad University of Medical Sceince
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Traumatic patients between 18-65 years old with diffuse axonal injury grade3 & 4 who do not need surgery, cannot eat sufficiently and are considered to stay a minimum of 96 hours in intensive care unit Exclusion criteria: Patients less than 18 years old, who are expected to stay less than 96 hours DNR (Do Not Resuscitate; no code, no escalation) in first 12 hours of admission. Enteral feeding cannot be started within 48 hours of admission. Admission BMI of less than 18.5 kg/m2 Past medical history of Terminal illness, diabetes, Liver or kidney dysfunctions, Immunometabolic diseases, pancreatitis Refused consent
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality. Timepoint: 28th day mortality. Method of measurement: Searching for the patient via HIS system or asking The patient's relatives.;Duration of hospital stay. Timepoint: Day 14 of intervention. Method of measurement: Days of hospital stay in the first 14 days of intervention.;Severity of disease. Timepoint: Day 0, 7 and 14 of intervention. Method of measurement: APACHE Score II.;Duration of mechanical ventilation. Timepoint: Day 14 of intervention. Method of measurement: Days of mechanical ventilation in the first 14 days of intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| CRP Level. Timepoint: Day 0, 7 and 14 of intervention. Method of measurement: Laboratory Test.;Prealbumin Level. Timepoint: Day 0, 7 and 14 of intervention. Method of measurement: Laboratory Test.;Fasting Blood Sugar Level. Timepoint: Day 0, 7 and 14 of intervention. Method of measurement: Laboratory Test.;Electrolytes Level(Magnesium, Sodium, Phosphorous, Ptassium). Timepoint: Day 0, 7 and 14 of intervention. Method of measurement: Laboratory Test.;Lipid Profile((LDL.C,TG,Total cholesterol, HDL.C). Timepoint: Day 0, 7 and 14 of intervention. Method of measurement: Laboratory Test.;Liver Function Tests(ALT, AST, Total Billirubin). Timepoint: Day 0, 7 and 14 of intervention. Method of measurement: Laboratory Test.;Total Lymphocytes Count. Timepoint: Day 0, 7 and 14 of intervention. Method of measurement: Laboratory Test.;Mid Arm Circumference. Timepoint: Day 0, 7 and 14 of intervention. Method of measurement: Measurement (cm).;SGA Malnutrition Assessment. Timepoint: Day 0, 7 and 14 of intervention. Method of measurement: SGA Malnutrition Assessment Tool. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Kazemi
Mashad University of Medical Science
Outcome results
None listed