Prophylactic antibiotic. Prophylactic antibiotic therapy
Conditions
Interventions
Intervention 1: In the first group the prophylactic regimen consists of Cefazolin 2 g IV before sternal incision followed by 1 g IV every 6 hours for 72 hours. Intervention 2: In the second group the
Treatment - Drugs
In the second group the prophylactic regimen consists of Cefazolin 2 g IV plus Gentamicin 1.5mg/kg IV before sternal incision followed by Cefazolin 1 g IV every 6 hours plus Gentamicin 1.5mg/kg IV eve
In the first group the prophylactic regimen consists of Cefazolin 2 g IV before sternal incision followed by 1 g IV every 6 hours for 72 hours.
Sponsors
Vice chancellor for research of Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria are informed written consent; Age between 40 and 75 years; Elective CABG surgery; Use of the cardiopulmonary pump during surgery. Exclusion criteria are history of infectious disease and use of antibiotic during previous week; Renal failure (baseline serum creatinine > 2mg/dl); systemic disease and drugs causing immunosuppression; together with other cardiac surgery (valvular surgery); Reoperation; Ejection fraction < 35%; history of sensitivity to cephalosporin or Gentamicin.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Surgical wound infection. Timepoint: 3, 7, 21 and 30 days after cardiac surgery. Method of measurement: observation - culture. | — |
Secondary
| Measure | Time frame |
|---|---|
| Creatinine. Timepoint: 2 -4 days after surgery. Method of measurement: Laboratory kit - mg/dl. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfshin Gholipour Baradari MD
Mazandaran University Of Medical Sciences
Outcome results
None listed