Acute myocardial infarction. ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction
Conditions
Interventions
Intervention 1: Intervention group: Oral colchicine (Modava, Tehran) 1mg followed by 0.5 mg after PCI. Intervention 2: Control group: Placebo of colchicine was administered at the dose of 1 mg followe
Sponsors
Deputy of Research and Technology of Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who are candidates for the Primary PCI Pain or chest discomfort greater than or equal to 20 minutes, less than or equal to 12 hours, and ST elevation = 1 mm in the adjacent limb leads and precordial leads except for V2, V3, or ST elevation = 2 mm in V2, V3 in men or ST height = 1.5 mm in V2, V3 in women. Obtain informed consent from all patients before enrollment
Exclusion criteria
Exclusion criteria: Patients who are only undergoing angiography for diagnostic purposes and do not undergo PCI Patients who have been treated with Colchicine due to chronic illness Colchicine intolerance history Glumerolar filtration Rate less than 30 ml/min and Dialysis patients Malignancy and infection Oral steroids or NSAIDs ( Except for aspirin) within 72 hours prior to PCI Use of CYP 3A4 / P-glycoprotein inhibitor drugs (Ritonavir / Ketoconazole / Clarithromycin / Cyclosporine / Diltiazem / Vrapaemia) Patients who suffered cardiac arrest, cardiogenic shock (systolic pressure less than 90), VF, or under CPR in emergency setting Start angina more than 12 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coronary blood flow and myocardial perfusion. Timepoint: during angiography. Method of measurement: TIMI flow criteria and observations during the angiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hs-CRP. Timepoint: baseline and 48 hours after PCI. Method of measurement: blood sample.;TNT. Timepoint: baseline and 6 hours and 24 hours and 48 hours after PCI. Method of measurement: blood sample.;P-selectin. Timepoint: baseline and 24 hours after PCI. Method of measurement: blood sample.;30 day MACE. Timepoint: one month after PCI. Method of measurement: follow-up visit or phone call. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Seyed Hossein Hosseini
Tehran University of Medical Sciences
Outcome results
None listed