Condition 1: Hemodialysis patients. Condition 2: Hemodialysis patients. Condition 3: Hemodialysis patients. Renal failure Renal failure Renal failure
Conditions
Interventions
Intervention 1: Control Group: Placebo as 600 milligram tablet, twice daily, every 12 hours, per oral for 6 weeks, made from micro-crystalline cellulose, lactose, corn starch, sorbitol, talk (2% of to
Placebo
Treatment - Drugs
Control Group: Placebo as 600 milligram tablet, twice daily, every 12 hours, per oral for 6 weeks, made from micro-crystalline cellulose, lactose, corn starch, sorbitol, talk (2% of total tablet weigh
Intervention Group: N-acetylcysteine with trade name A.C.C, as 600 milligram tablet, made by Hexal company, given twice daily (every 12 hours), per oral for 6 weeks.
Sponsors
Vice Chancellor for Development, Research and Technology of Ahvaz Jondishapour University of Medical
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: all of the chronic hemodialysis patients due to end stage renal disease more than 18 years old and at least three months has been past from starting of hemodialysis. Exclusion criteria: 1) Every acute disease leads to hospitalization from one month before trial 2) Allergy to N-acetylcysteine 3) Hepatic cirrhosis 4) Using vitamin E or C or every known antioxidant from 2 weeks before until 2 weeks after treatment with N-acetylcysteine 5) Congestive heart failure or ejection fraction less than 35% 6) Non using of N-acetylcysteine or placebo more than 20% of total drug 7) Normal basal serum total oxidative stress level.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Level of Total Oxidative Stress. Timepoint: Before intervention and 6 weeks after intervention. Method of measurement: With ELISA method, micromol/liter with (T.A.C) Kit made by Glory company. | — |
Secondary
| Measure | Time frame |
|---|---|
| Urticaria. Timepoint: before intervention and 6 weeks after intervention. Method of measurement: Visual.;Itching. Timepoint: before intervention and 6 weeks after intervention. Method of measurement: Visual. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShokouh Shayanpour
Ahvaz Jondishapour University of Medical Sciences
Outcome results
None listed