The effect of anesthesia agents on intracytoplasmic injection of sperm outcome

Comparison of the effect of two drug combinations remifentanil propofol and ketamine propofol on hemodynamic parameters and reproductive outcome after intracytoplasmic sperm injection in patients undergoing oocyte retrieval with general anesthesia a double blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20120110008677N7

Enrollment

200

Registered

2021-10-29

Start date

2021-11-21

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention group: Induction of anesthesia in group ketamine propofol, ketofol drug containing: propofol 1-1.5 mg/kg with 0.5 mg/kg ketamine. Lidocaine 40 mg is prescribed to reduce

Eligibility

Sex/Gender

Female

Age

18 Years to 41 Years

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists Classification grade I and II Age less than 42 years

Exclusion criteria

Exclusion criteria: Preimplantation genetic screening cycles Signs of poor ovarian response History of cardiorespiratory disease Chronic drug use Allergy to anesthetics

Design outcomes

Primary

Measure	Time frame
Fertilization rate. Timepoint: One day after intracytoplasmic injection of sperm. Method of measurement: Stereo microscope.;Clinical pregnancy. Timepoint: Six to seven weeks after embryo transfer. Method of measurement: Ultrasonography.	—

Secondary

Measure	Time frame
Response time to voice commands. Timepoint: Following discontinuation of anesthesia agents. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarnoush Farzi

Mehr medical institute

farnoush_farzi@yahoo.com+98 13 3376 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026