Major depressive disorder. Major depression
Conditions
Interventions
Intervention 1: Intervention group: 20 mg fluoxetine plus 1500 IU vitamin D daily after lunchfor 8 weeks. Intervention 2: Placebo group:
20 patients will receive 20 mg fluoxetin and placebo for 8 wee
Placebo
Intervention group: 20 mg fluoxetine plus 1500 IU vitamin D daily after lunchfor 8 weeks
Placebo group:
20 patients will receive 20 mg fluoxetin and placebo for 8 weeks
Sponsors
Vice-chancellor for research, Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Willing to participate; Clinical diagnosis of major depressive disorder; A score =15 in the 17-item Hamilton Depression Rating Scale; Age 18 – 65 years; Good health status based on medical history; No antidepressant or dietary supplement use during the previous two months. Exclusion criteria: Substance abuse; Pregnancy and lactation.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression severity. Timepoint: At baseline, weeks 2, 4, 6, 8. Method of measurement: Hamilton Depression Rating Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein. Timepoint: At baseline, after weeks 2, 4, 6, 8. Method of measurement: ELISA.;Total antioxidant capacity. Timepoint: 8 weeks. Method of measurement: FRAP.;IL-6. Timepoint: At baseline, after weeks 2, 4, 6, 8. Method of measurement: ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNayereh Khoraminya
Tehran University of Medical Science
Outcome results
None listed