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Assessment the effect of combining letrozole and gonadotropin on the IVF / ICSI cycle success rate

Comparison the effect of combining letrozole and gonadotropin with gonadotropin alone on the IVF / ICSI cycle success rate in women with endometriosis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20120104008611N12
Enrollment
94
Registered
2021-03-19
Start date
2021-04-04
Completion date
Unknown
Last updated
2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometriosis. Endometriosis, unspecified

Interventions

Intervention 1: Intervention group: On the third day of menstruation, all participants will be evaluated with TVS for measuring endometrial thickness and antral follicle counts. Then, the GnRH agonist

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Women with 18 to 35 year-old Body mass index lower than 30 kg/m2 In her first IVF cycle Without any uterine diseases Sperm motility of at least 20% in sperm analysis Anti-mullerin hormone greater than 1 ng/ml

Exclusion criteria

Exclusion criteria: Women who underwent letrozole or clomiphene therapy for induction ovulation Sever endometriosis with DIE Submucosal myoma with any size and intramural myoma greater than 3 cm was detected in transvaginal ultrasound Withdraw to participation

Design outcomes

Primary

MeasureTime frame
The total prescribed dosage of Cinnal-f, and HMG. Timepoint: Once, at the trigger day. Method of measurement: Will be calculated by gynecologic.;The estradiol level. Timepoint: Once, at the trigger day. Method of measurement: Blood sample.;The oocyte number, and quality. Timepoint: Once, at puncture day. Method of measurement: According to the oocyte puberty degree, the oocyte quality will be determined.;The embryo quality. Timepoint: Once, after in vitro fertilization. Method of measurement: According to Gardner system.

Secondary

MeasureTime frame
Biochemical pregnancy. Timepoint: Once, 14 days after fetus transfer. Method of measurement: Blood sampling.;Clinical pregnancy. Timepoint: Once, 6 to 8 weeks after fetus transfer. Method of measurement: Pregnancy sac observation in transvaginal ultrasound.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamideh Pakniat

Tehran University of Medical Sciences

pakniat110@yahoo.com+98 21 8608 9089

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026