Comparison between Magnesium sulphate and Paracetamol in intravenous regional anesthesia

Comparison between magnesium sulfate and paracetamol in Analgesic effect and venous blood gas alterations during Intravenous Regional Anesthesia with Lidocaine

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201112254046N2

Enrollment

Registered

2012-01-08

Start date

2011-12-03

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

local anesthetics. Anesthesia-regional

Interventions

Intervention 1: Control group:they will receive Lidocaine 0.5% , 3 mg/kg plus normal saline intravenousely by the total volume of 40 ml . Intervention 2: Magnesium Sulphate ( intervention) group:the

Treatment - Drugs

Control group:they will receive Lidocaine 0.5% , 3 mg/kg plus normal saline intravenousely by the total volume of 40 ml .

Magnesium Sulphate ( intervention) group:they will receive Lidocaine 0.5%, 3 mg/kg plus magnesium sulphate 15%, 10 ml (Magnesium Sulphate 20% Hypertonic, made by Pastor Institude-iran)and normal salin

Paracetamol(intervention) group:they will receive Lidocaine 0.5%, 3 mg/kg plus Paracetamol (Apotel,made by Unipharma, Greece) 1000 mg and normal saline intravenousely by the total volume of 40 ml.

Eligibility

Sex/Gender

All

Age

15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. Age between 15 to 65 years 2. Appropriate general condition as American Society of Anesthesiologist (ASA) class I and II 3. Upper extremity surgeries 4. Operation time less than 2 hours Exclusion criteria: 1. Any allergic reaction to Lidocaine, Acetaminophen or Magnesium Sulphate 2. Any cyanosis in affected limb 3.Any opioid or psychoactive drug abuse

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Sensory block. Timepoint: During and after operation. Method of measurement: Pinprick test.;Motor block. Timepoint: During and after operation. Method of measurement: Remove of all hand movements.;Venous blood gas. Timepoint: Before and after procedure. Method of measurement: Venous blood sample.;Pain. Timepoint: During the operation and 24 hours after that. Method of measurement: Visual Analog Scale.	—

Measure

Time frame

Sensory block. Timepoint: During and after operation. Method of measurement: Pinprick test.;Motor block. Timepoint: During and after operation. Method of measurement: Remove of all hand movements.;Venous blood gas. Timepoint: Before and after procedure. Method of measurement: Venous blood sample.;Pain. Timepoint: During the operation and 24 hours after that. Method of measurement: Visual Analog Scale.

—

Secondary

Measure	Time frame
Saturation of oxygen. Timepoint: Durig operation and 24 hours after that. Method of measurement: Pulse oximetery.;Blood pressure. Timepoint: During operation and 24 hours after that. Method of measurement: Blood pressure manometer.;Heart rate. Timepoint: During operation and 24 hours after that. Method of measurement: Pulse oximetery.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMrs.Taheri

Anesthesiology research center-Shahid Beheshti University ,M.C

a.r.c@sbmu.ac.ir+98 21 2243 2572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026