Neonatal sepsis. P36.8
Conditions
Interventions
Intervention 1: Control group: treated with Amikacin twice dose of 10 mg/ kg body weight daily that is within one hour intravenous infusion. Intervention 2: Case group: treated with amikacin one dose
Treatment - Drugs
Control group: treated with Amikacin twice dose of 10 mg/ kg body weight daily that is within one hour intravenous infusion.
Case group: treated with amikacin one dose of 15 mg /kg body weight that is within one hour intravenous infusion.
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Term Infants with the clinical signs of sepsis in premature newborn infants admitted Bou Ali Sina Hospital of Sari treated with Ampicillin plus Amikacin. Exclusion criteria : fetal age more than 42 Weeks and less than 37 weeks; Low birth weight; having congenital heart disease and asphyxia; not treated with Ampicillin and Amikacin at the age of 7 days; renal and hearing congenital disorders; prescription medications that have toxic effect on renal and auditory systems; neonatal meningitis; pathologic icter and TORCH Infections.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The treatment of SDL peak in therapeutic range. Timepoint: Sixty minutes after intramuscular administration or 30 minutes after intravenous administration in the range 15 -30. Method of measurement: Serum samples.;The treatment of through SDL in non-toxic range. Timepoint: Sixty minutes after intramuscular administration or 30 minutes after intravenous administration in the range 15 -30. Method of measurement: Serum samples. | — |
Secondary
| Measure | Time frame |
|---|---|
| Potential renal side effects. Timepoint: Before the next dose. Method of measurement: Serum samples.;Potential hearing side effects. Timepoint: Before the Next Dose. Method of measurement: Auditory brainstem response and audiometry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mohammadsadegh Rezai
Mazandaran University of Medical Sciences
Outcome results
None listed