COVID-19. COVID-19, virus identified
Conditions
Interventions
Intervention 1: Intervention group: For 7 days, once daily, 10 ml of bacteriophage cocktail solution with a titer of one trillion pfu (Plaque Forming Units) per ml is nebulized once a day. Interventio
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
4 Years to No maximum
Inclusion criteria
Inclusion criteria: Children and adults with moderate to severe COVID-19 (moderate: Evidence of pulmonary involvement or symptoms on imaging. severe: Respiratory rate more than 30 times per minute + percentage of blood oxygen saturation less than 93% + infiltration more than 50% in the lungs) Having one of the following symptoms: Dry cough, severe weakness and fatigue, dyspnea, chest pain, fever greater than 38° C Less than 3 days have passed since the first sign started Definitive diagnosis of Covid-19 based on RT-PCR test "or" Involvement of a maximum of 3 or 4 pulmonary lobes with an area less than one third of the volume of each lobe "or" Infection of one or two lobes with a larger area in the patient's CT scan view
Exclusion criteria
Exclusion criteria: Patient who has previously had COVID-19 or has been hospitalized for COVID-19 Participate in any other clinical trial for the treatment of COVID-19 Bradycardia, abnormal primary ECG Active cancer, immunodeficiency or treatment with immunosuppressive drugs Underlying liver and kidney disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Secondary pulmonary bacterial infection. Timepoint: Before the intervention and days 1 to 7, and 14 and 21 days after treatment. Method of measurement: Sputum culture, CT scan, clinical signs (fever, cough? ...). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood oxygen saturation. Timepoint: 10 and 14 days after treatment. Method of measurement: Palsoxymeter.;Survival rate. Timepoint: After hospitalization. Method of measurement: Recoed of recovery or death.;Number of hospitalization days. Timepoint: Initiation of hospitalization until after discharge or death. Method of measurement: Number of days.;Number of days of intubation. Timepoint: Start intubation until the tube separates or death. Method of measurement: Number of days.;Number of days in the ICU. Timepoint: Start entering the ICU until discharge from the ICU. Method of measurement: Number of days.;Body temprature. Timepoint: Daily until 14 days. Method of measurement: Thermometer.;Cough. Timepoint: Daily until 14 days. Method of measurement: Observation and asking the patient.;Fatigue. Timepoint: Daily until 14 days. Method of measurement: Observation and asking the patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mohammad Sadegh Rezai
Mazandaran University of Medical Sciences
Outcome results
None listed