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Evaluation of the effect of Ivermectin in treatment of patients admitted with COVID-19

Double-blind placebo-controlled clinical trial of evaluating the effectiveness of Ivermectin in treatment of patients admitted with COVID-19 in 2021

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20111224008507N5
Enrollment
1000
Registered
2021-02-22
Start date
2021-02-19
Completion date
Unknown
Last updated
2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 infection. COVID-19, virus identified

Interventions

Intervention 1: Intervention group: The intervention group will use Iranian standard treatment protocol for COVID-19 in addition to Ivermectin 3 mg oral tablet at a dose of 0.4 mg/kg manufactured by A
Weight 80-5, 24 mg and weight over 80, 0.4 mg/kg. Intervention 2: Control group: In the control group, placebo tablets made by Alborz Daru of Iran with the same shape, color and weight based dose of i

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
5 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with positive coronavirus rapid test or RT-PCR Age>5 years Weight >15 kg No treatment with antiviral drugs before and during the study Informed consent for participation

Exclusion criteria

Exclusion criteria: Underlying liver and kidney disease Patients with acquired immunodeficiency Pregnancy and lactation

Design outcomes

Primary

MeasureTime frame
Reduction in persistent cough. Timepoint: Daily until improvement. Method of measurement: Question from the patient.;Negative RT-PCR result. Timepoint: 6 days after the intervention. Method of measurement: RT-PCR.;The main complaints recovery time. Timepoint: Daily until symptoms resolve. Method of measurement: Checklist containing patient complaints.;Mortality. Timepoint: Daily. Method of measurement: Record in checklist.;Drug side effect (Wheezing, itching, skin rash, edema, and hypotension). Timepoint: Daily. Method of measurement: Question from the patient.;Reduction in tachypnea. Timepoint: Daily. Method of measurement: Medical record.;Oxigen saturation >94%. Timepoint: Daily. Method of measurement: Medical record.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammad Sadegh Rezai

Mazandaran University of Medical Sciences

drmsrezaii@yahoo.com+98 11 3334 2334

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 12, 2026