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Effect of co-administration of Amantadine and Aspirin on fatigue in patients with multiple sclerosis

Therapeutic effect of co-administration of Amantadine and Aspirin on fatigue in patients with multiple sclerosis: a randomized placebo-controlled double-blind study

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201112208430N3
Enrollment
45
Registered
2012-01-15
Start date
2008-06-19
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple scerosis. Multiple sclerosis

Interventions

Intervention 1: Intervention group:Aspirin,500 mg oral tablet, once daily for 42 days and Amantadine,100-mg oral capsule , once daily for 42 days. Intervention 2: Control group:Amantadine,100-mg oral
Treatment - Drugs
Intervention group:Aspirin,500 mg oral tablet, once daily for 42 days and Amantadine,100-mg oral capsule , once daily for 42 days.
Control group:Amantadine,100-mg oral capsule , once daily for 42 days and oral placebo tablet for 42 days .

Sponsors

Kerman Neuroscience Reserch Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Definite diagnosis of multiple sclerosis; age between 20-50 years; disability scour =6 on the extended disability status scale patients; fatigue score =4 on the fatigue severity scale. Exclusion criteria: Patients with current or recent (within 2 months ago) use of medications or allergy to asprin or amantadin.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Fatigue Severity Scale. Timepoint: Before intervention,30 days after intervention,42days after intervention. Method of measurement: Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAkbar Hamzei Moghaddam

Kerman Neuroscience Research Center

a_hamzehei@kmu.ac.ir+98 34 1246 7139

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026