Head Trauma. Diffuse brain injury
Conditions
Interventions
Intervention 1: Case group: Drug Citicholine 500 mg/q6h slow IV infusion. Intervention 2: Control group: Without any intervention.
Treatment - Drugs
Case group: Drug Citicholine 500 mg/q6h slow IV infusion
Sponsors
Neuroscience Research Center (NSRC), Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1) 18-65 years of age. 2) Providing informed consent to be included in the study. 3) Absence of major traumatic lesion in chest, abdomen or limbs. 4) Admission within 24 hours following trauma. 5) Absence of major cardiac diseases. 6) Absence of cardiac disease, hyperlipidemia, diabetes and hypertension. Exclusion criteria: 1) Admission after 24 hours following the trauma. 2) History of heart disease, hyperlipidemia, diabetes, hypertension and coagulation disorders. 3) History of malignancy. 4) Multitrauma patients with major trauma of chest, abdomen or limbs. 5) Patients with focal brain lesions such as contusion and brain hematoma which necessitates surgical drainage. 7) Unstable hemodynamic. 8) Pregnancy. 9) Surgery including general, orthopedic or gynecologic surgeries within first 24 hours after trauma. 10) CPR or resuscitation within 24 hours after trauma. 11) Death or discharge within study period.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fetuin-A. Timepoint: 1st(Before intervention), 6th day(After intervention) and 12th day(After intervention). Method of measurement: Plasma levels.;Matrix Gla Protein (MGP). Timepoint: 1st(Before intervention), 6th(After intervention), 12th day(After intervention). Method of measurement: Plasma levels.;Level of Consciousness. Timepoint: Daily(From the first day of admission to the last day of study). Method of measurement: Assessment of GCS by examiner. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ghaffar Shokouhi
Department of Neurosurgery, Tabriz University of Medical Sciences
Outcome results
None listed