The effect of fennel extract on antimullerian hormone and ultrasound criteria in infertile women with Occult premature ovarian failure

The effect of fennel extract on antimullerian hormone and ultrasound criteria in infertile women with Occult premature ovarian failure: a randomized controlled clinical trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20111219008459N15

Enrollment

Registered

2023-02-05

Start date

2023-04-04

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Occult premature ovarian insufficiency.

Interventions

Intervention 1: Intervention group: 30 mg fennel capsules manufactured by Barnage Essential Oil Company will be used. One capsule will be consumed daily for 2 months. Intervention 2: Control group: Pl

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1) Evidence suggesting occult premature ovarian failure: antimullerian hormone > 1, or reduction of ovarian follicular reserve by transvaginal ultrasound (reduction of antral follicles less than 6 in each ovary) 2) Presence of menstrual cycles 3) Age 20-40 years 4) Having Both ovaries 5) No other causes of female infertility including fallopian tube disorders, endocrine system disorders and uterine disorders, endometriosis, hyperprolactinemia and sexual disorders based on the patient's medical record. 6) Not using complementary herbal medicines in the last three months

Exclusion criteria

Exclusion criteria: 1) Alcohol consumption and smoking 2) Obesity, BMI >30 3) Willingness to use donated eggs 4) Having a history of cancer, radiotherapy and chemotherapy 5) People with ovarian cysts and uterine myoma 6) People being treated with the antibiotic ciprofloxacin (46) 7) Presence of menopause symptoms (hot flashes, night sweats)

Design outcomes

Primary

Measure	Time frame
Comparison of the number of ovarian antral follicles in the group receiving fennel capsules and the control group. Timepoint: At the beginning of the study (before the start of the intervention) 2 months after the start of the intervention. Method of measurement: Real time transvaginal ultrasound with Madison v20 brand, which is made in South Korea.;Comparison of AMH levels in the group receiving fennel capsules and the control group. Timepoint: At the beginning of the study (before the start of the intervention) 2 months after the start of the intervention. Method of measurement: AMH laboratory kit.	—

Measure

Time frame

Comparison of the number of ovarian antral follicles in the group receiving fennel capsules and the control group. Timepoint: At the beginning of the study (before the start of the intervention) 2 months after the start of the intervention. Method of measurement: Real time transvaginal ultrasound with Madison v20 brand, which is made in South Korea.;Comparison of AMH levels in the group receiving fennel capsules and the control group. Timepoint: At the beginning of the study (before the start of the intervention) 2 months after the start of the intervention. Method of measurement: AMH laboratory kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Banaei

Tabriz University of Medical Sciences

future.maryam@yahoo.com+98 41 3479 6770

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026