Bipolar disorder. Bipolar affective disorder, unspecified
Conditions
Interventions
Intervention 1: Case group 1: folic acid,oral tab 5mg,once a day,for six weeks. Intervention 2: Case group 2:vitamin B6,oral tab
40mg,towice a day, for six weeks. Intervention 3: Control group:place
Treatment - Drugs
Placebo
Case group 1: folic acid,oral tab 5mg,once a day,for six weeks
Case group 2:vitamin B6,oral tab
40mg,towice a day, for six weeks
Control group:placebo,oral tab,once a day,for six weeks
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:1)Patients age between 18 to 45 years old according to birth certificate.2)Diagnosis of bipolar mood disorder I with recent episode of mania according to DSM IV TR diagnosis criteria.3)Roling out diagnosis of schizophrenia,delirium,anorexia nervosa,bulimia,autism,substance abuse(at least during 3 months ago ),mental retardation,adhd.4)Absence of psychiatric hospitalization history during 3 months ago.5)Absence of seizure history6)Absence of severe allergy history.7)Filling out informed consent.8)Absence of allergic history to sodium valproate. Exclusion criteria:1)Patients who evaluate at risk of suicide or homicide according to psychiatric diagnosis.2)Female patients are doubted for pregnancy, should test serum pregnancy test and will exclude from study if it is positive.3)Patients who take other drugs such as antimanic drugs that could not be able to stop them in two weeks before study or during it.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of mania. Timepoint: Baseline,End of the third week,End of the six week. Method of measurement: Jung Mania Rating Scale(YMRS).;Cognitive scale. Timepoint: Baseline,End of the third week,End of the six week. Method of measurement: Mini Mental State Examination (MMSE). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Ebrahimi
Mashhad University of Medical Sciences
Outcome results
None listed