acetaminphen toxicity. Poisoning by nonopioid analgesics, antipyretics and antirheumatics (Salicylate)s
Conditions
Interventions
Intervention 1: The group A (only intravenous N-acetylcystein or NAC) was managed by IV NAC with 150mg/kg infused in 200cc of 5% dextrose water (5%DW) in 30 minutes, followed by a 4 hour infusion of 5
Treatment - Drugs
The group A (only intravenous N-acetylcystein or NAC) was managed by IV NAC with 150mg/kg infused in 200cc of 5% dextrose water (5%DW) in 30 minutes, followed by a 4 hour infusion of 50mg/kg of NAC in
In group B (oral and IV NAC), oral NAC was given by 140mg/kg in 200cc of 5%DW. If vomiting occurred in any patient during one hour after the ingestion of the oral NAC then 10mg metoclopramide was give
Sponsors
Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: The inclusion criteria: Patients with acetaminophen poisoning; ingesting the toxic acetaminophen dose (=7.5g); aged = 18 years old; coming to the hospital before 8 hours after acetaminophen ingestion. The exclusion criteria: Less than 7.5g acetaminophen ingesting; aged under 18 years old; coming to the hospital after 8 hours after acetaminophen ingestion; vomiting two times after oral NAC was given; pregnant patients; those who had risk factors for hepatic toxicity (e.g. those who had hepatic cirrhosis; chronic ethanol ingestion; usage of substances that induce cytochrome P450 enzyme activity including rifampin; phenobarbital; isoniazid; phenytoin and carbamazepine).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anaphylactoid reactions. Timepoint: during NAC (N-acetylcysteine) infusion. Method of measurement: observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNastaran Eizadi Mood
Isfahan University of Medical Sciences
Outcome results
None listed