sepsis. Sepsis, unspecified
Conditions
Interventions
Intervention 1: 2 Sachets of probiotic VSL 3 (containing lactobacillus, bifidobacterium and streptococus species)/day for 7 days. Intervention 2: 2 sachet of placebo/day for 7 days.
Treatment - Drugs
Placebo
2 Sachets of probiotic VSL 3 (containing lactobacillus, bifidobacterium and streptococus species)/day for 7 days
2 sachet of placebo/day for 7 days
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1) critically ill patients admitted to the surgical ICU with positive SIRS and APACHE II score 15 to 30; 2) receiving enteral nutrition; 3) aging 18-40 years old; 4) expected to stay in ICU for at least 7 days. Exclusion criteria: 1) pregnant and lactating women; 2) patients who cannot tolerate enteral nutrition; 3) unstable hemodynamic; 4) smoking; 5) immune disorders and diabetes mellitus; 6) intestinal obstruction; 7) intestinal ischemia; 8) Patients who are expected to expire in the next 24 hours; 9) HIV-positive; 10) cancer; 11) bedsore; 12) bone marrow, liver or lung transplantation; 13) short bowel syndrome, pancreatitis and kidney or liver failure; 14) receiving Lactulose, mannitol, and glutamine during the study; 15) patients undergoing GI procedures (endoscopy, resection of the bowel and GI surgeries) during the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammation. Timepoint: days 1, 4, 7. Method of measurement: IL6, PCT.;Coagulation. Timepoint: days 1, 4, 7. Method of measurement: protein C.;Oxidative stress. Timepoint: days 1, 4, 7. Method of measurement: TAC, MDA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality. Timepoint: days 1, 4, 7. Method of measurement: being live or dead. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSarvin Sanaie
Tabriz University of Medical Sciences
Outcome results
None listed