A comparison of various bolus doses of intravenous oxytocin on intraoperative hemodynamic changes in elective cesarean section

A comparison of various bolus doses of intravenous oxytocin on intraoperative hemodynamic changes and drug side effects in elective cesarean section under spinal anesthesia

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201112138391N1

Enrollment

120

Registered

2012-01-07

Start date

2010-12-12

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obstetric conditions. Sequelae of complication of pregnancy, childbirth and the puerperium

Interventions

Intervention 1: prescription of 1ml water for injection in addition of infusion of oxytocin after delivery during cesarean section in control group. Intervention 2: prescription of 2 units oxytocin b

Placebo

Treatment - Drugs

prescription of 1ml water for injection in addition of infusion of oxytocin after delivery during cesarean section in control group

prescription of 2 units oxytocin bolus in addition of infusion of this drug after delivery during cesarean section in intervention group

prescription of 5 units oxytocin bolus in addition of infusion of this drug after delivery during cesarean section in intervention group

Eligibility

Sex/Gender

Female

Age

15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Healthy pregnant women without any underlying disease who have been planned to undergo elective cesarean section to give birth to a single live newborn. Exclusion criteria included: 1) failure of spinal anesthesia and need to general anesthesia; 2) block level higher than T4; 3) atonia of uterine during or after surgery; 4) surgical complication leading to sever & acute bleeding; 5) duration of surgery more than 1 hour; 6) administration any uterotonic drug during or after surgery; 7) need to blood transfusion during & after transfusion; 8) macrosomia; 9) polyhydroamnious.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Survey hemodynamic changes. Timepoint: Before drug administraion & 1min, 3min, 5min & 10 min. Method of measurement: Manual manometer & stethoscope& digital monitiring.	—

Secondary

Measure	Time frame
Blood hemoglobin. Timepoint: Before & 24 hours after surgery. Method of measurement: H1 automatic device.;Headache. Timepoint: During surgery, after prescription. Method of measurement: Asking patient.;Vomiting. Timepoint: During surgery, after prescription. Method of measurement: Asking patient.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbdollahzadeh, Mehrsima MD

Guilan University of Medical Sciences

abdollahzadeh@gums.ac.ir+98 13 1322 5624

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026